Aceclofenac, (2-[2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl]oxyacetic acid), a nonsteroidal antiinflammatory drug (NSAID) has been indicated for various painful indicationsand proved as effective as other NSAIDs with lower indications of gastro-intestinal adverse effects and thus, resulted in a greater compliance with treatment . Aceclofenac is practically insoluble. For poorly soluble orally administered drugs, the rate of absorption is often controlled by the rate of dissolution. Clear aceclofenac-loaded soft capsules have been prepared to accelerate the absorption . The rate of dissolution can be increased by increasing the surface area of available drug by various methods (micronization, complexation and solid dispersion) . The dissolution of a drug can also be influenced by disintegration time of the tablets. Faster disintegration of tablets delivers a fine suspension of drug particles resulting in a higher surface area and faster dissolution.
Of all the orally administered dosage forms, tablet is most preferred because of ease of administration, compactness and flexibility in manufacturing. Because of changes in various physiological functions associated with aging including difficulty in swallowing, administration of intact tablet may lead to poor patient compliance and ineffective therapy. The paediatric and geriatrics patients are of particular concern. To overcome this, dispersible tabletsand fast-disintegrating tablets have been developed. Most commonly used methods to prepare these tablets are; freeze-drying/Lyophilization , tablet molding and direct-compression methods . Lyophilized tablets show a very porous structure, which causes quick penetration of saliva into the pores when placed in oral cavity , . The main disadvantages of tablets produced are, in addition to the cost intensive production process, a lack of physical resistance in standard blister packs and their limited ability to incorporate higher concentrations of active drug . Moulded tablets dissolve completely and rapidly. However, lack of strength and taste masking are of great concern , . Main advantages of direct compression are, low manufacturing cost and high mechanical integrity of the tablets , . Therefore, direct-compression appears to be a better option for manufacturing of tablets. The fast disintegrating tablets prepared by direct compression method, in general, are based on the action established by superdisintegrants such as croscarmellose sodium, crospovidone and sodium starch glycolate. The effect of functionality differences of the superdisintegrants on tablet disintegration has been studied . The objective of the present work was to develop fast dispersible aceclofenac tablets and to study the effect of functionality differences of superdisintegrants on the tablet properties and to provide information on the storage conditions of these tablets.