High Pressure Liquid Chromatographic Analysis and Dissolution of Famotidine in Tablet Formulation

Authors: Mutaz A. Sheikh Salem^a; Hanan N. Alkaysi^a; Adnan A. Badwan^b

Abstract A reversed phase high pressure liquid chromatographic method was developed for the quantitation of famotidine in tablet formulation using a mobile phase consisting of 0.1M phosphate buffer (84%), acetonitrile (11%) and methanol (5%) at a pH of 6.5. The detection wavelength was set at 285 nm. The method is precise and adaptable for quality control purposes. The use of the analytical method hi studying tablet dissolution is described.

Keywords: HPLC; Famotidine; Mobile Phase; Tab