Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film Coating

The goal of this study was to determine which combination of excipients would result in a tablet core that would be suitable for use in an aqueous enteric film-coating process. A relatively simple formulation of microcrystalline cellulose (MCC) and partially pregelatinized starch (P-PGS) was found to provide the necessary properties.MCC in the formulation provides the compactability needed to produce a tablet that will withstand the mechanical stresses of the film-coating process. P-PGS provides the dissolution characteristics and is responsible for the stability characteristics in this moisture-sensitive, enteric film-coated application. It was also found that P-PGS could be used to reduce the deleterious effects of superdisintegrants in formulations.