Friday, May 1, 2009

tocopherol

Title: Chemical compounds containing tocopherol and at least one additional pharmaceutical active substrate
Abstract: and R′, R″ and R′″ are equal to H or methyl stands for tocopherol and A stands for C═X, SOm, X or CH2, whereby X is equal to 0, S or NR1 (when n≧1) or S or NR1 (when n=0), and B means a grouping X—R2—Y with Y equal to C═X, SOm or C(XR3)R4, and n is equal to 0 to 6, and m stands for 1 or 2, whereby R1 stands for H, C1 to C10-alkyl, Het or an aryl or Het radical that is bonded via a C1 to C6-spacer, and whereby R2 is selected from the group alkylene, arylene or Het spacers and combinations thereof, whereby the latter are linked to one another either directly or via radical A or via grouping Xo-A-Xp, whereby o and p are equal to 0, 1 or 2, and the latter can be the same or different, and whereby R3 and R4 stand for H, C1 to C10-alkyl, Het or an aryl or Het radical that is bonded via a C1 to C6 spacer. in which R stands for the unchanged portion of a variable pharmaceutical active ingredient molecule, B stands for a spacer, and Toc with the formula Compounds in the form of their racemates, enantiomers or diastereomers with general formula I

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